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Found 4 matching student topics

Displaying 1–4 of 4 results

Strain-level characterisation and visualisation of microbial communities associated with inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder driven by complex interactions between environmental, microbial and immune-mediated factors. An unfavourable shift in gut microbiome composition, known as dysbiosis, is now considered a key feature of IBD, however it is unclear how specific microorganisms and their interactions with host cells contribute to disease onset and progression. Previous IBD studies have been largely limited to older sequencing methods with low resolution. Furthermore, these studies have predominantly focused on bacterial populations, …

Study level
PhD
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Microbiome Research

Giant viruses in the human gut microbiome

The human body is home to a vast ecosystem of microorganisms including bacteria, archaea, fungi, viruses, and bacteriophages that make up the human microbiota. These microbes and their collective genetic material, known as the microbiome, influence a wide range of physiological functions including nutrient production and absorption, the development and regulation of our immune system, protection against potential pathogens, and even our mood and mental health. While distinct microbial communities exist throughout the body, the gut microbiome has gained particular …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Microbiome Research

Defining human immune responses to a healthy gut microbiome

Many human diseases are thought to involve interactions between the gut microbiome and the immune system which shape the nature and function of immunity. These interactions between host and environment are thought to be critical regulators of health and disease.In autoimmune diseases many studies have associated presence or absence of particular microbial species with diseases and some studies have shown influence of disease-related genetics on the composition of the gut microbiome. However, no studies to date have formally addressed the …

Study level
PhD
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Microbiome Research

Development of a multiplexed gut micro-bioreactor for functional screening of gut microbiome

The human microbiome refers to the collection of micro-organisms that are living symbiotically in the human body (defined as the “microbiota”), their genetic material as well as the surrounding environmental habitat.It is now appreciated that the microbiome plays an important role in human health and diseases. Various disease states have been linked to dysregulation of the gut microbiota, including neurodegenerative, cardiovascular and metabolic diseases. The composition of the gut microbiome can also affect responses to therapies, most notably in cancer …

Study level
PhD, Master of Philosophy
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies
Centre for Microbiome Research

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